![]() Accidental poisoning with a plant Colchicum autumnale: report of two cases. Colchicine-induced rhabdomyolysis: an autopsy case. Colchicine poisoning as a mode of suicide. In the early 1950s, demecolcine (substance F) was used for the treatment of leukemia, lymphoid hemoblastoses and Hodgkin’s disease. Colchicine was approved by the FDA for the treatment and prophylaxis of gout flares, and has also been used with varying success in the treatment of familial Mediterranean fever, alcoholic, posthepatitic and primary biliary cirrhosis, psoriasis, Behçet’s disease, aphthous stomatitis, linear IgA dermatosis, relapsing polychondritis, Sweet’s syndrome, scleroderma, amyloidosis, leukocytoclastic vasculitis, epidermolysis bullosa, and dermatomyositis. In modern practice, the alkaloid colchicine is only used as a specific treatment for gouty arthritis. Besides the main active principle colchicine present in amounts up to 0.6%, the corm contains several other alkaloids. as the first user for the selective and specific treatment of gout. The disease ( podagra) was common at the time, its main causes being overconsumption of alcoholic drinks and food, and thus referred to as the ‘disease of kings,’ though the disease was recognized by Hippocrates in the fifth-century B.C., who called it ‘the unwalkable disease.’ Some refer to Byzantine Christian physician, Alexander of Tralles in the 6th century A.D. autumnale in the treatment of gout was by the 5th century physician, Jacob Psychristus. ![]() According to Byzantine historians, first use of C. Modern phytonyms refer to the land of Colchis, a mythical place close to Armenia. The plant was called by different names through the ages: ephemera, finger of Hermes, pater noster, and tue -chiens. ![]() In Babylonia, it was used for swelling poison of the limbs, scorpion sting, head and eye diseases, as well as for breast pain. ![]() Dioscorides and Galen described corms toxic and lethal, as they taste delicious and increase the desire to eat more its leaves, corm and seeds are all poisonous. Corm and seeds were well known to ancient Greeks and Romans for their remedial property in gout, rheumatism, arthritis, dropsy, gonorrhea and enlarged prostate. Native to grassy meadows and woods and river banks in southeastern Ireland, England, the Netherlands and Denmark, and at altitudes between 400 and 1,200 m ranges east to Poland and south to Spain and central Italy and North Africa. ![]()
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